Bentov, I. and Werner, H: Insulin-like growth factor-1. In: Handbook of Biologically Active Peptides, Second edition, ed. by Kastin, A., Elsevier Press, San Diego 2013, pp. 1627-1632.
Bitelman, C., Sarfstein, R., Sarig, M., Attias-Geva, Z., Fishman, A., Werner, H. and Bruchim, I: IGF1R-directed targeted therapy enhances the cytotoxic effect of chemotherapy in endometrial cancer. Cancer Lett 2013, 335:153-159.Bruchim I, Werner H: Targeting IGF-1 signaling pathways in gynecologic malignancies. Expert opinion on therapeutic targets 2013, 17(3):307-320. [PDF]
Hermani A, Shukla A, Medunjanin S, Werner H, Mayer D: Insulin-like growth factor binding protein-4 and -5 modulate ligand-dependent estrogen receptor-alpha activation in breast cancer cells in an IGF-independent manner. Cell Signal 2013, 25(6):1395-1402. [PDF]
Sarfstein R, Friedman Y, Attias-Geva Z, Fishman A, Bruchim I, Werner H: Metformin downregulates the insulin/IGF-I signaling pathway and inhibits different uterine serous carcinoma (USC) cells proliferation and migration in p53-dependent or -independent manners. PLoS One 2013, 8(4):e61537. [PDF]
Sarfstein R, Werner H: Minireview: Nuclear Insulin and Insulin-like Growth Factor-1 Receptors: A Novel Paradigm in Signal Transduction. Endocrinology 2013, 154(5):1672-1679. [PDF]Amichay K, Kidron D, Attias-Geva Z, Schayek H, Sarfstein R, Fishman A, Werner H, Bruchim I: BRCA1 is expressed in uterine serous carcinoma (USC) and controls insulin-like growth factor I receptor (IGF-IR) gene expression in USC cell lines. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2012, 22(5):748-754. [PDF]
Attias-Geva Z, Bentov I, Kidron D, Amichay K, Sarfstein R, Fishman A, Bruchim I, Werner H: p53 Regulates insulin-like growth factor-I receptor gene expression in uterine serous carcinoma and predicts responsiveness to an insulin-like growth factor-I receptor-directed targeted therapy. European journal of cancer (Oxford, England : 1990) 2012, 48(10):1570-1580. [PDF]
Sarfstein R, Pasmanik-Chor M, Yeheskel A, Edry L, Shomron N, Warman N, Wertheimer E, Maor S, Shochat L, Werner H: Insulin-like growth factor-I receptor (IGF-IR) translocates to nucleus and autoregulates IGF-IR gene expression in breast cancer cells. The Journal of biological chemistry 2012, 287(4):2766-2776. [PDF]
Schayek H, Bentov I, Jacob-Hirsch J, Yeung C, Khanna C, Helman LJ, Plymate SR, Werner H: Global methylation analysis identifies PITX2 as an upstream regulator of the androgen receptor and IGF-I receptor genes in prostate cancer. Horm Metab Res 2012, 44(7):511-519. [PDF]
Werner H: Tumor suppressors govern insulin-like growth factor signaling pathways: implications in metabolism and cancer. Oncogene 2012, 31(22):2703-2714. [PDF]
Werner, H., Attias-Geva, Z., Bentov, I., Sarfstein, R., Schayek, H., Weinstein, D. and Bruchim, I: Cancer genes, tumor suppressors, and regulation of IGF-1R gene expression in cancer. In: Insulin-like growth factors and cancer: from basic biology to therapeutics. ed. by LeRoith, D., Springer Science, New York, 2012 pp.159-177.Werner H, Bruchim I: IGF-1 and BRCA1 signalling pathways in familial cancer. Lancet Oncol 2012, 13(12):e537-544. [PDF]
Attias-Geva Z, Bentov I, Fishman A, Werner H, Bruchim I: Insulin-like growth factor-I receptor inhibition by specific tyrosine kinase inhibitor NVP-AEW541 in endometrioid and serous papillary endometrial cancer cell lines. Gynecol Oncol 2011, 121(2):383-389. [PDF]
Attias-Geva Z, Bentov I, Ludwig DL, Fishman A, Bruchim I, Werner H: Insulin-like growth factor-I receptor (IGF-IR) targeting with monoclonal antibody cixutumumab (IMC-A12) inhibits IGF-I action in endometrial cancer cells. Eur J Cancer 2011, 47(11):1717-1726. [PDF]
Rubovitch V, Shachar A, Werner H, Pick CG: Does IGF-1 administration after a mild traumatic brain injury in mice activate the adaptive arm of ER stress? Neurochem Int 2011, 58(4):443-446. [PDF]
Sarfstein R, Bruchim I, Fishman A, Werner H: The mechanism of action of the histone deacetylase inhibitor vorinostat involves interaction with the insulin-like growth factor signaling pathway. PLoS One 2011, 6(9):e24468. [PDF]
Werner, H. and Chantelau, E: Differences in bioactivity between human insulin and insulin analogues approved for therapeutic use – compilation of reports from the past 20 years. Diabetol. Metab. Syndrome 2011, 3:13.Werner H, Weinstein D, Yehezkel E, Laron Z: Controversies in the use of insulin analogues. Expert Opin Biol Ther 2011, 11(2):199-209. [PDF]
Aiello A, Pandini G, Sarfstein R, Werner H, Manfioletti G, Vigneri R, Belfiore A: HMGA1 protein is a positive regulator of the insulin-like growth factor-I receptor gene. European journal of cancer (Oxford, England : 1990) 2010, 46(10):1919-1926. [PDF]
Rubovitch V, Edut S, Sarfstein R, Werner H, Pick CG: The intricate involvement of the Insulin-like growth factor receptor signaling in mild traumatic brain injury in mice. Neurobiol Dis 2010, 38(2):299-303. [PDF]
Sarfstein R, Belfiore A, Werner H: Werner et al. Identification of Insulin-Like Growth Factor-I Receptor (IGF-IR) Gene Promoter-Binding Proteins in Estrogen Receptor (ER)-Positive and ER-Depleted Breast Cancer Cells. Cancers 2010, 2(3):1642-1643. [PDF]
Sarfstein R, Belfiore A, Werner H: Identification of Insulin-Like Growth Factor-I Receptor (IGF-IR) Gene Promoter-Binding Proteins in Estrogen Receptor (ER)-Positive and ER-Depleted Breast Cancer Cells. Cancers (Basel) 2010, 2(2):233-261. [PDF]
Schayek H, Bentov I, Rotem I, Pasmanik-Chor M, Ginsberg D, Plymate SR, Werner H: Transcription factor E2F1 is a potent transactivator of the insulin-like growth factor-I receptor (IGF-IR) gene.Growth Horm IGF Res 2010, 20(1):68-72. [PDF]
Schayek H, Bentov I, Sun S, Plymate SR, Werner H: Progression to metastatic stage in a cellular model of prostate cancer is associated with methylation of the androgen receptor gene and transcriptional suppression of the insulin-like growth factor-I receptor gene. Exp Cell Res 2010, 316(9):1479-1488. [PDF]
Schayek H, Seti H, Greenberg NM, Sun S, Werner H, Plymate SR: Differential regulation of insulin-like growth factor-I receptor gene expression by wild type and mutant androgen receptor in prostate cancer cells. Molecular and cellular endocrinology 2010, 323(2):239-245. [PDF]
Weinstein D, Simon M, Yehezkel E, Laron Z, Werner H: The mitogenicity of insulin analogues in vitro relative to insulin and IGF-I – Response to Kazda et al. Diabetes Metab Res Rev 2010, 26(5):348. [PDF]
Werner H, Bruchim I: Basic and clinical significance of IGF-I-induced signatures in cancer. BMC medicine 2010, 8:2. [PDF]
Yehezkel E, Weinstein D, Simon M, Sarfstein R, Laron Z, Werner H: Long-acting insulin analogues elicit atypical signalling events mediated by the insulin receptor and insulin-like growth factor-I receptor. Diabetologia 2010, 53(12):2667-2675. [PDF]
Bruchim I, Attias Z, Werner H: Targeting the IGF1 axis in cancer proliferation. Expert opinion on therapeutic targets 2009, 13(10):1179-1192. [PDF]
Schayek H, Haugk K, Sun S, True LD, Plymate SR, Werner H: Tumor suppressor BRCA1 is expressed in prostate cancer and controls insulin-like growth factor I receptor (IGF-IR) gene transcription in an androgen receptor-dependent manner. Clinical cancer research : an official journal of the American Association for Cancer Research 2009, 15(5):1558-1565. [PDF]
Seti H, Leikin-Frenkel A, Werner H: Effects of omega-3 and omega-6 fatty acids on IGF-I receptor signalling in colorectal cancer cells. Archives of physiology and biochemistry 2009, 115(3):127-136. [PDF]
Weinstein D, Simon M, Yehezkel E, Laron Z, Werner H: Insulin analogues display IGF-I-like mitogenic and anti-apoptotic activities in cultured cancer cells. Diabetes Metab Res Rev 2009, 25(1):41-49. [PDF]
Werner H, Bruchim I: The insulin-like growth factor-I receptor as an oncogene. Archives of physiology and biochemistry 2009, 115(2):58-71. [PDF]
Bentov I, Narla G, Schayek H, Akita K, Plymate SR, LeRoith D, Friedman SL, Werner H: Insulin-like growth factor-i regulates Kruppel-like factor-6 gene expression in a p53-dependent manner.Endocrinology 2008, 149(4):1890-1897.
Klammt J, Pfaffle R, Werner H, Kiess W: IGF signaling defects as causes of growth failure and IUGR.Trends Endocrinol Metab 2008, 19(6):197-205.
Werner H, Weinstein D, Bentov I: Similarities and differences between insulin and IGF-I: structures, receptors, and signalling pathways. Archives of physiology and biochemistry 2008, 114(1):17-22.
Maor S, Papa MZ, Yarden RI, Friedman E, Lerenthal Y, Lee SW, Mayer D, Werner H: Insulin-like growth factor-I controls BRCA1 gene expression through activation of transcription factor Sp1.Horm Metab Res 2007, 39:179-185.
Maor S, Yosepovich A, Papa MZ, Yarden RI, Mayer D, Friedman E, Werner H: Elevated insulin-like growth factor-I receptor (IGF-IR) levels in primary breast tumors associated with BRCA1 mutations.Cancer letters 2007, 257(2):236-243.
Werner H, Idelman G, Rubinstein M, Pattee P, Nagalla SR, Roberts CT, Jr.: A novel EWS-WT1 gene fusion product in desmoplastic small round cell tumor is a potent transactivator of the insulin-like growth factor-I receptor (IGF-IR) gene. Cancer letters 2007, 247(1):84-90.
Yuen JS, Cockman ME, Sullivan M, Protheroe A, Turner GD, Roberts IS, Pugh CW, Werner H, Macaulay VM: The VHL tumor suppressor inhibits expression of the IGF1R and its loss induces IGF1R upregulation in human clear cell renal carcinoma. Oncogene 2007, 26(45):6499-6508.
Attias Z, Werner H, Vaisman N: Folic acid and its metabolites modulate IGF-I receptor gene expression in colon cancer cells in a p53-dependent manner. Endocr Relat Cancer 2006, 13(2):571-581.
Bentov I, Werner H: Insulin-like growth factor-I. In: Handbook of Biologically Active Peptides. edn. Edited by Kastin A. San Diego: Elsevier Press; 2006: 1385-1392.
Glait C, Tencer L, Ravid D, Sarfstein R, Liscovitch M, Werner H: Caveolin-1 up-regulates IGF-I receptor gene transcription in breast cancer cells via Sp1- and p53-dependent pathways. Exp Cell Res 2006, 312(19):3899-3908.
Maor S, Mayer D, Yarden RI, Lee AV, Sarfstein R, Werner H, Papa MZ: Estrogen receptor regulates insulin-like growth factor-I receptor gene expression in breast tumor cells: involvement of transcription factor Sp1. The Journal of endocrinology 2006, 191(3):605-612.
Sarfstein R, Maor S, Reizner N, Abramovitch S, Werner H: Transcriptional regulation of the insulin-like growth factor-I receptor gene in breast cancer. Molecular and cellular endocrinology 2006, 252(1-2):241-246.
Sarfstein R, Werner H: The WT1 Wilms’ tumor suppressor gene is a downstream target for insulin-like growth factor-I (IGF-I) action in PC12 cells. Journal of neurochemistry 2006, 99(3):818-826.
Werner H, Maor S: The insulin-like growth factor-I receptor gene: a downstream target for oncogene and tumor suppressor action. Trends in Endocrinology and Metabolism 2006, 17:236-242.
Karl M, Potier M, Schulman IH, Rivera A, Werner H, Fornoni A, Elliot SJ: Autocrine activation of the local insulin-like growth factor I system is up-regulated by estrogen receptor (ER)-independent estrogen actions and accounts for decreased ER expression in type 2 diabetic mesangial cells.Endocrinology 2005, 146(2):889-900.
Nahor I, Abramovitch S, Engeland K, Werner H: The p53-family members p63 and p73 inhibit insulin-like growth factor-I receptor gene expression in colon cancer cells. Growth Hormone IGF Res 2005, 15:388-396.
Ravid D, Maor S, Werner H, Liscovitch M: Caveolin-1 inhibits cell detachment-induced p53 activation and anoikis by upregulation of insulin-like growth factor-I receptors and signaling.Oncogene 2005, 24(8):1338-1347.
Eshet R, Gil-Ad I, Apelboym O, Segev Y, Phillip M, Werner H: Modulation of brain insulin-like growth factor I (IGF-I) binding sites and hypothalamic GHRH and somatostatin levels by exogenous growth hormone and IGF-I in juvenile rats. J Mol Neurosci 2004, 22(3):179-188.
Rubinstein M, Idelman G, Plymate SR, Narla G, Friedman SL, Werner H: Transcriptional activation of the insulin-like growth factor I receptor gene by the Kruppel-like factor 6 (KLF6) tumor suppressor protein: potential interactions between KLF6 and p53. Endocrinology 2004, 145(8):3769-3777.
Shahrabani-Gargir L, Pandita TK, Werner H: Ataxia-telangiectasia mutated gene controls insulin-like growth factor I receptor gene expression in a deoxyribonucleic acid damage response pathway via mechanisms involving zinc-finger transcription factors Sp1 and WT1. Endocrinology 2004, 145(12):5679-5687.
Werner H, Katz J: The emerging role of the insulin-like growth factors in oral biology. J Dent Res2004, 83(11):832-836.
Bentov I, LeRoith D, Werner H: The WT1 Wilms’ tumor suppressor gene: a novel target for insulin-like growth factor-I action. Endocrinology 2003, 144(10):4276-4279.
Idelman G, Glaser T, Roberts CT, Jr., Werner H: WT1-p53 interactions in insulin-like growth factor-I receptor gene regulation. The Journal of biological chemistry 2003, 278(5):3474-3482.
Werner H, Roberts CT, Jr.: The IGFI receptor gene: a molecular target for disrupted transcription factors. Genes Chromosomes Cancer 2003, 36(2):113-120.
Ayalon D, Glaser T, Werner H: Transcriptional regulation of IGF-I receptor gene expression by the PAX3-FKHR oncoprotein. Growth Horm IGF Res 2001, 11(5):289-297.
Shalita-Chesner M, Katz J, Shemer J, Werner H: Regulation of insulin-like growth factor-I receptor gene expression by tumor necrosis factor-alpha and interferon-gamma. Molecular and cellular endocrinology 2001, 176(1-2):1-12.
Maor SB, Abramovitch S, Erdos MR, Brody LC, Werner H: BRCA1 suppresses insulin-like growth factor-I receptor promoter activity: potential interaction between BRCA1 and Sp1. Mol Gen Metab2000, 69:130-136.
Werner H, Le Roith D: New concepts in regulation and function of the insulin-like growth factors: implications for understanding normal growth and neoplasia. Cellular and molecular life sciences : CMLS 2000, 57(6):932-942.
Werner H, LeRoith D: New concepts in regulation and function of the insulin-like growth factors: implications for understanding normal growth and neoplasia. Cell Mol Life Sci 2000, 57:932-942.
Werner H, Shalita-Chesner M, Abramovitch S, Idelman G, Shaharabani-Gargir L, Glaser T: Regulation of the insulin-like growth factor-I receptor gene by oncogenes and antioncogenes: implications in human cancer. Mol Genet Metab 2000, 71(1-2):315-320.
de Lacerda L, Carvalho JA, Stannard B, Werner H, Boguszewski MC, Sandrini R, Malozowski SN, Leroith D, Underwood LE: In vitro and in vivo responses to short-term recombinant human insulin-like growth factor-1 (IGF-I) in a severely growth-retarded girl with ring chromosome 15 and deletion of a single allele for the type 1 IGF receptor gene. Clin Endocrinol (Oxf) 1999, 51(5):541-550.
Katz J, Nasatzky E, Werner H, Le Roith D, Shemer J: Tumor necrosis factor alpha and interferon gamma–induced cell growth arrest is mediated via insulin-like growth factor binding protein-3.Growth Horm IGF Res 1999, 9(3):174-178.
Ohlsson C, Kley N, Werner H, LeRoith D: p53 regulates insulin-like growth factor-I (IGF-I) receptor expression and IGF-I-induced tyrosine phosphorylation in an osteosarcoma cell line: interaction between p53 and Sp1. Endocrinology 1998, 139(3):1101-1107.
Hernandez-Sanchez C, Werner H, Roberts CT, Jr., Woo EJ, Hum DW, Rosenthal SM, LeRoith D:Differential regulation of insulin-like growth factor-I (IGF-I) receptor gene expression by IGF-I and basic fibroblastic growth factor. J Biol Chem 1997, 272(8):4663-4670.
Werner H, Le Roith D: The insulin-like growth factor-I receptor signaling pathways are important for tumorigenesis and inhibition of apoptosis. Critical reviews in oncogenesis 1997, 8(1):71-92.
Werner H, LeRoith D: The insulin-like growth factor-I receptor signaling pathways are important for tumorigenesis and inhibition of apoptosis. Crit Rev Oncogenesis 1997, 8:71-92.
Karnieli E, Werner H, Rauscher FJ, 3rd, Benjamin LE, LeRoith D: The IGF-I receptor gene promoter is a molecular target for the Ewing’s sarcoma-Wilms’ tumor 1 fusion protein. The Journal of biological chemistry 1996, 271(32):19304-19309.
Werner H, Karnieli E, Rauscher FJ, III, LeRoith D: Wild type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene. Proc Natl Acad Sci USA 1996, 93:8318-8323.
Werner H, Karnieli E, Rauscher FJ, LeRoith D: Wild-type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene. Proc Natl Acad Sci U S A 1996, 93(16):8318-8323.
Werner H, LeRoith D: The role of the insulin-like growth factor system in human cancer. Adv Cancer Res 1996, 68:183-223.
Werner H, Roberts CT, Jr., Rauscher FJ, 3rd, LeRoith D: Regulation of insulin-like growth factor I receptor gene expression by the Wilms’ tumor suppressor WT1. J Mol Neurosci 1996, 7(2):111-123.
Beitner-Johnson D, Werner H, Roberts CT, Jr., LeRoith D: Regulation of insulin-like growth factor I receptor gene expression by Sp1: physical and functional interactions of Sp1 at GC boxes and at a CT element. Molecular endocrinology (Baltimore, Md ) 1995, 9(9):1147-1156.
LeRoith D, Werner H, Beitner-Johnson D, Roberts CT, Jr.: Molecular and cellular aspects of the insulin-like growth factor I receptor. Endocr Rev 1995, 16(2):143-163.
LeRoith D, Werner H, Neuenschwander S, Kalebic T, Helman LJ: The role of the insulin-like growth factor-I receptor in cancer. Ann N Y Acad Sci 1995, 766:402-408.
Malozowski S, Parmer TG, Trojan S, Merriam GR, Gibori G, Roberts CT, Jr., LeRoith D, Werner H, Zilberstein M: Growth hormone (GH) modulates insulin-like growth factor I (IGF-I) and type I IGF receptor mRNA levels in the ovary of prepubertal GH-deficient rats. Eur J Endocrinol 1995, 132(4):497-501.
Werner H, Hernandez-Sanchez C, Karnieli E, Leroith D: The regulation of IGF-I receptor gene expression. Int J Biochem Cell Biol 1995, 27(10):987-994.
Werner H, LeRoith D: Insulin-like growth factor I receptor: structure, signal transduction, and function. Diabetes Reviews 1995, 3:28-37.
Werner H, Shen-Orr Z, Rauscher FJ, 3rd, Morris JF, Roberts CT, Jr., LeRoith D: Inhibition of cellular proliferation by the Wilms’ tumor suppressor WT1 is associated with suppression of insulin-like growth factor I receptor gene expression. Molecular and cellular biology 1995, 15(7):3516-3522.
Phillip M, Werner H, Palese T, Kowarski AA, Stannard B, Bach LA, LeRoith D, Roberts CT, Jr.:Differential accumulation of insulin-like growth factor-I in kidneys of pre- and postpubertal streptozotocin-diabetic rats. J Mol Endocrinol 1994, 12(2):215-224.
Rubini M, Werner H, Gandini E, Roberts CT, Jr., LeRoith D, Baserga R: Platelet-derived growth factor increases the activity of the promoter of the insulin-like growth factor-1 (IGF-1) receptor gene. Exp Cell Res 1994, 211(2):374-379.
Werner H, Adamo M, Roberts CT, Jr, LeRoith D: Molecular and cellular aspects of Insulin-like growth factor action. In: Vitamins and Hormones. Volume 48, edn. Edited by Litwack G. San Diego, CA: Academic Press; 1994: 1-58.
Werner H, Adamo M, Roberts CT, Jr., LeRoith D: Molecular and cellular aspects of insulin-like growth factor action. Vitam Horm 1994, 48:1-58.
Werner H, Rauscher FJ, 3rd, Sukhatme VP, Drummond IA, Roberts CT, Jr., LeRoith D: Transcriptional repression of the insulin-like growth factor I receptor (IGF-I-R) gene by the tumor suppressor WT1 involves binding to sequences both upstream and downstream of the IGF-I-R gene transcription start site. J Biol Chem 1994, 269(17):12577-12582.
Adamo ML, Lanau F, Neuenschwander S, Werner H, LeRoith D, Roberts CT, Jr.: Distinct promoters in the rat insulin-like growth factor-I (IGF-I) gene are active in CHO cells. Endocrinology 1993, 132(2):935-937.
Eshet R, Werner H, Klinger B, Silbergeld A, Laron Z, LeRoith D, Roberts CT, Jr.: Up-regulation of insulin-like growth factor-I (IGF-I) receptor gene expression in patients with reduced serum IGF-I levels. J Mol Endocrinol 1993, 10(2):115-120.
LeRoith D, Werner H, Faria TN, Kato H, Adamo M, Roberts CT, Jr.: Insulin-like growth factor receptors. Implications for nervous system function. Ann N Y Acad Sci 1993, 692:22-32.
LeRoith D, Werner H, Phillip M, Roberts CT, Jr.: The role of insulin-like growth factors in diabetic kidney disease. American journal of kidney diseases : the official journal of the National Kidney Foundation 1993, 22(5):722-726.
Shemer J, Yaron A, Werner H, Shao ZM, Sheikh MS, Fontana JA, LeRoith D, Roberts CT, Jr.:Regulation of insulin-like growth factor (IGF) binding protein-5 in the T47D human breast carcinoma cell line by IGF-I and retinoic acid. J Clin Endocrinol Metab 1993, 77(5):1246-1250.
Werner H, Re GG, Drummond IA, Sukhatme VP, Rauscher FJ, 3rd, Sens DA, Garvin AJ, LeRoith D, Roberts CT, Jr.: Increased expression of the insulin-like growth factor I receptor gene, IGF1R, in Wilms tumor is correlated with modulation of IGF1R promoter activity by the WT1 Wilms tumor gene product. Proc Natl Acad Sci U S A 1993, 90(12):5828-5832.
Werner H, Roberts CT, Jr, Raizada MK, Bondy CA, Adamo M, LeRoith D: Developmental regulation of the insulin and insulin-like growth factor receptors in the central nervous system. In: Receptors in the developing nervous system. Volume 1, edn. Edited by Zagon IS, McLaughlin PJ. London: Chapman and Hall; 1993: 107-128.
Bondy C, Werner H, Roberts CT, Jr., LeRoith D: Cellular pattern of type-I insulin-like growth factor receptor gene expression during maturation of the rat brain: comparison with insulin-like growth factors I and II. Neuroscience 1992, 46(4):909-923.
Bondy CA, Werner H, Roberts CT, Jr, LeRoith D: Cellular pattern of Type I insulin-like growth factor receptor gene expression during maturation of the rat brain: comparison with insulin-like growth factors I and II. Neuroscience 1992, 46:909-923.
LeRoith D, McGuinness M, Shemer J, Stannard B, Lanau F, Faria TN, Kato H, Werner H, Adamo M, Roberts CT, Jr.: Insulin-like growth factors. Biol Signals 1992, 1(4):173-181.
LeRoith D, Werner H, Burguera B, Roberts CT, Jr., Mulroney S, Haramati A: The insulin-like growth factor family of peptides, binding proteins and receptors: their potential role in tissue regeneration.Adv Exp Med Biol 1992, 321:21-28; discussion 29-30.
Mulroney SE, Haramati A, Werner H, Bondy C, Roberts CT, Jr., LeRoith D: Altered expression of insulin-like growth factor-I (IGF-I) and IGF receptor genes after unilateral nephrectomy in immature rats. Endocrinology 1992, 130(1):249-256.
Werner H, Bach MA, Stannard B, Roberts CT, Jr., LeRoith D: Structural and functional analysis of the insulin-like growth factor I receptor gene promoter. Molecular endocrinology (Baltimore, Md ) 1992, 6(10):1545-1558.
Hernandez E, Hurwitz A, Botero L, Ricciarelli E, Werner H, Roberts CT, Jr, LeRoith D, Adashi E:Insulin-like growth factor receptor gene expression in the rat ovary: divergent regulation of distinct receptor species. Molecular Endocrinology 1991, 5:1799-1805.
Hernandez ER, Hurwitz A, Botero L, Ricciarelli E, Werner H, Roberts CT, Jr., LeRoith D, Adashi EY:Insulin-like growth factor receptor gene expression in the rat ovary: divergent regulation of distinct receptor species. Mol Endocrinol 1991, 5(12):1799-1805.
LeRoith D, Adamo M, Werner H, Roberts CT, Jr: Insulin-like growth factors and their receptors as growth regulators in normal physiology and pathological states. Trends Endocrinol Metab 1991, 2:134-139.
Masters BA, Werner H, Roberts CT, Jr., LeRoith D, Raizada MK: Insulin-like growth factor I (IGF-I) receptors and IGF-I action in oligodendrocytes from rat brains. Regul Pept 1991, 33(2):117-131.
Masters BA, Werner H, Roberts CT, Jr., LeRoith D, Raizada MK: Developmental regulation of insulin-like growth factor-I-stimulated glucose transporter in rat brain astrocytes. Endocrinology 1991, 128(5):2548-2557.
Werner H, Stannard B, Bach MA, Roberts CT, Jr., LeRoith D: Regulation of insulin-like growth factor I receptor gene expression in normal and pathological states. Adv Exp Med Biol 1991, 293:263-272.
Werner H, Woloschak M, Stannard B, Shen-Orr Z, Roberts CT, Jr, LeRoith D: Insulin-like growth factor receptor: Molecular Biology, Heterogeneity, and Regulation. In: Insulin-like growth factors: Molecular and Cellular Aspects. edn. Edited by LeRoith D. Boca Raton, FL: CRC Press; 1991: 17-47.
Bondy CA, Werner H, Roberts CT, Jr., LeRoith D: Cellular pattern of insulin-like growth factor-I (IGF-I) and type I IGF receptor gene expression in early organogenesis: comparison with IGF-II gene expression. Mol Endocrinol 1990, 4(9):1386-1398.
Burguera B, Werner H, Sklar M, Shen-Orr Z, Stannard B, Roberts CT, Jr., Nissley SP, Vore SJ, Caro JF, LeRoith D: Liver regeneration is associated with increased expression of the insulin-like growth factor-II/mannose-6-phosphate receptor. Mol Endocrinol 1990, 4(10):1539-1545.
Werner H, Stannard B, Bach MA, LeRoith D, Roberts CT, Jr.: Cloning and characterization of the proximal promoter region of the rat insulin-like growth factor I (IGF-I) receptor gene. Biochemical and biophysical research communications 1990, 169(3):1021-1027.
Lowe WL, Jr., Adamo M, Werner H, Roberts CT, Jr., LeRoith D: Regulation by fasting of rat insulin-like growth factor I and its receptor. Effects on gene expression and binding. J Clin Invest 1989, 84(2):619-626.
Werner H, Raizada MK, Mudd LM, Foyt HL, Simpson IA, Roberts CT, Jr., LeRoith D: Regulation of rat brain/HepG2 glucose transporter gene expression by insulin and insulin-like growth factor-I in primary cultures of neuronal and glial cells. Endocrinology 1989, 125(1):314-320.
Werner H, Woloschak M, Adamo M, Shen-Orr Z, Roberts CT, Jr., LeRoith D: Developmental regulation of the rat insulin-like growth factor I receptor gene. Proc Natl Acad Sci U S A 1989, 86(19):7451-7455.
Adamo M, Werner H, Farnsworth W, Roberts CT, Jr., Raizada M, LeRoith D: Dexamethasone reduces steady state insulin-like growth factor I messenger ribonucleic acid levels in rat neuronal and glial cells in primary culture. Endocrinology 1988, 123(5):2565-2570.